become a mainstay in the clinic. However, the pace of innovation in synthetic biology is breathtaking, and the early clinical results are undeniably promising. The prospect of a highly specific, effective, and potentially more affordable cancer treatment is a powerful motivator. As we continue to unravel the complex and intimate relationship between our bodies and the trillions of microbes that call us home, we are not just finding new ways to treat cancer; we are fundamentally redefining our relationship with the "enemy within." The future of cancer therapy may indeed be microbial, a future where we turn our oldest adversaries into our most sophisticated allies in the fight for life.
Reference:
- https://sciencenews.dk/en/harnessing-genetically-engineered-escherichia-coli-to-combat-cancer
- https://breakingcancernews.com/2024/12/02/how-an-e-coli-bacteria-strain-is-helping-us-fight-cancer/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11148798/
- https://pubmed.ncbi.nlm.nih.gov/20704985/
- https://jitc.bmj.com/content/8/Suppl_3/A233.1
- https://www.courthousenews.com/scientists-explore-fighting-cancer-with-sound-controlled-bacteria/
- https://www.jcancer.org/v10p4765.htm
- https://aacrjournals.org/clincancerres/article/27/1/96/83414/Intratumoral-Injection-of-Clostridium-novyi-NT
- https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.914575/full
- https://ecancer.org/en/news/23828-engineered-bacteria-guide-car-t-cells-to-poorly-infiltrated-solid-tumours
- https://www.researchgate.net/figure/Listeria-cancer-vaccines-in-clinical-trials_tbl1_326617180
- https://www.researchgate.net/publication/359450918_Ultrasound-controllable_engineered_bacteria_for_cancer_immunotherapy
- https://www.geneonline.com/magnetobacterial-microrobots-designed-for-targeted-drug-delivery-in-complex-biological-environments/
- https://www.cancer.gov/news-events/cancer-currents-blog/2024/engineering-ecoli-bacteria-cancer-immunotherapy
- https://pmc.ncbi.nlm.nih.gov/articles/PMC2064865/
- https://www.mdpi.com/2227-9059/7/2/36
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5464893/
- https://physicsworld.com/a/nanoengineered-bacteria-provide-light-activated-cancer-therapy/
- https://pubmed.ncbi.nlm.nih.gov/33046513/
- https://www.clinicaltrials.gov/study/NCT01924689
- https://www.engineering.columbia.edu/about/news/modifying-e-coli-diagnose-and-treat-colorectal-cancer
- https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.642316/full
- https://www.mdpi.com/2076-393X/6/3/48
- https://ascopubs.org/doi/10.1200/jco.2010.28.15_suppl.e15542
- https://www.eurekalert.org/news-releases/999936
- https://www.caltech.edu/about/news/fighting-cancer-with-sound-controlled-bacteria
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11208082/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11330796/
- https://proceedings.aiche.org/sbe/conferences/international-conference-on-crispr-technologies/2017/proceeding/paper/crispr-based-synthetic-gene-circuits-controllable-gene-therapies
- https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1425529/full
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7560980/
- https://www.advancedsciencenews.com/how-can-bacteria-robots-improve-cancer-therapy/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12069239/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10802201/
- https://www.zmescience.com/science/ultrasound-controlled-bacteria-destroy-cancer-tumors/
- https://www.advancedsciencenews.com/light-activated-therapy-and-antibiotics-join-forces-to-improve-in-situ-cancer-vaccines/
- https://www.researchgate.net/publication/352471062_Engineered_NIR_light-responsive_bacteria_as_anti-tumor_agent_for_targeted_and_precise_cancer_therapy
- https://www.clinicaltrialvanguard.com/news/pembrolizumab-cnv-nt-combo-study-results-in-solid-tumors/
- https://www.drugtargetreview.com/news/112088/cancer-killing-t-cells-enhanced-by-engineered-bacteria/
- https://www.microbiometimes.com/engineered-bacteria-guide-car-t-cells-to-poorly-infiltrated-solid-tumors/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12034723/
- https://pubmed.ncbi.nlm.nih.gov/31209849/
- https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.1026248/full
- https://www.droracle.ai/articles/166261/what-is-the-role-of-microbiota-in-personalized-medicine-for-oncology-patients
- https://www.embopress.org/doi/10.15252/embr.202357040
- https://www.ted.com/talks/stephanie_culler_designing_microbiome_therapeutics_to_help_cure_cancer